1-Butanol → HCID 178433424, compound

HRID 1255912Notes

Reaction equation

HRID 1255912 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].[CH3:11][C:12](=O)[C:13](=O)[CH3:14].C([OH:21])CCC>CCOCC>[CH3:8][C:6]1[NH:5][C:4]2[C:3]([C:2](=[O:21])[N:7]=1)=[N:10][C:13]([CH3:14])=[C:12]([CH3:11])[N:9]=2

Participants

5

Reactant 3

HCID 2631-ButanolHCID 650ButanedioneHCID 5941456-Chloro-2-methylpyrimidine-4,5-diamine

Product 1

HCID 178433424HCID 178433424, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
77.5 °C

Procedure

A mixture of 6-chloro-2-methylpyrimidine-4,5-diamine (3.2 g, 20 mmol) and 2,3-butanedione (3.6 g, 42 mmol) in n-butanol (40 mL) was stirred at 75-80° C. for 1 h. After cooling, the reaction was diluted with Et2O (50 mL) and the solid collected by suction filtration. This was dried in vacuo affording, 2,6,7-trimethylpteridin-4(1H)-one (3.9 g), as a gold powder which was used in the next step without further purification.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid collected by suction filtration
  3. customThis was dried in vacuo
  4. customaffording
  5. custom2,6,7-trimethylpteridin-4(1H)-one (3.9 g), as a gold powder which was used in the next step without further purification

Sources & evidence

ORD record
ord-df84f7e9adf64644998898bfbc6ad2c8
Source dataset
uspto-grants-2013_06
Patent number
US08461164B2

Reaction notes

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