4-Ethynylcinnoline → 3-(cinnolin-4-ylethynyl)-N-[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]-4-methylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	4-Ethynylcinnoline	HCID 57775151	—
Reactant	N-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide	HCID 66736595	—
Product	3-(cinnolin-4-ylethynyl)-N-[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]-4-methylbenzamide	HCID 57775186	—

Reaction Steps

The title compound can be synthesized from 4-ethynylcinnoline and N-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide in a manner similar to that described for Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08461167B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-c1577e34d36d411c9da19678d4d26220
Source note	uspto-grants-2013_06