Triethylamine → HCID 86761877, compound

Participants

Reaction Steps

To a solution of crude tert-butyl (4-bromomethyl-3-trimethylsilylphenyl)trimethylsilylcarbamate (2.57 g, 5.98 mmol) in THF (10 mL) was added Et3N (1.3 mL, 8.97 mmol) and 1-methylpiperazine (1.1 mL, 8.92 mmol). After stirring for 1 h at rt, aq. NaHCO3 was added, and the mixture was extracted with EtOAc. The combined organic layer was dried over Na2SO4 (filtered, concentrated, and the resulting residue was purified by silica gel chromatography (eluted with 5% MeOH/DCM) to provide product as a pale yellow oil (1.60 g, 71%).

Provenance & Evidence