HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methanesulfonic Acid 2-[2-(2-{2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy}-ethoxy)-ethanol | HCID 69319925 | — |
| Reactant | methanesulfonic acid 2-{2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxy]-ethoxy}-ethyl ester | HCID 86618842 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methanesulfonic Acid 2-[2-(2-{2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester | HCID 87781253 | — |
Reaction Steps
Compound 32b was prepared as described hereinabove for Compound 32a, using Compound 29b (0.023 gram, 0.043 mmol), methanesulfonyl chloride (0.014 gram, 0.12 mmol) and triethylamine (0.021 gram, 0.021 mmol) in dichloromethane (2.3 ml), yielding 0.015 gram of the product (55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461166B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-46eabc0e22114d77819030fb4a0561dc |
| Source note | uspto-grants-2013_06 |