Hydrazine hydrate (1:1) → N4-Phenylquinazoline-4,6-diamine

Participants

Reaction Steps

A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol derivative terminating with a fifth reactive group, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety terminating with a reactive group.

Provenance & Evidence