HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → N4-Phenylquinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 6-Nitro-N-phenylquinazolin-4-amine | HCID 5328189 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | N4-Phenylquinazoline-4,6-diamine | HCID 5328187 | — |
Reaction Steps
A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney® Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety (terminating with a hydroxyl group).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461166B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-1bcbd8072ef14c7a9ae4b6e886275640 |
| Source note | uspto-grants-2013_06 |