HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N4-(4,5-dichloro-2-fluoro-phenyl)-7-[2-ethoxy-ethoxy]-quinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-{2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy}-ethanol | HCID 69266955 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N4-(4,5-dichloro-2-fluoro-phenyl)-7-[2-ethoxy-ethoxy]-quinazoline-4,6-diamine | HCID 69320196 | — |
Reaction Steps
Compound 29a is dissolved in a 9:1 mixture of EtOH:H2O at 85° C., a solution of hydrazine monohydrate in a Ra—Ni solution is added and the reaction mixture is stirred for 1 hour. The obtained solution is cooled and thereafter filtered over Celite®. The filtrate is evaporated under reduced pressure to afford Compound 41a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461166B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-c3f9aeb72e344eec902f390ec3b3b362 |
| Source note | uspto-grants-2013_06 |