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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1255980Generated: October 26, 2026

2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol → N4-(4,5-Dichloro-2-fluoro-phenyl)-7-{2-[2-(2-{2-[2-ethoxy-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-quinazoline-4,6-diamine

https://huagongshe.com/reaction/1255980

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanolHCID 69261526—
ReactantN4-(4,5-dichloro-2-fluoro-phenyl)-7-[2-ethoxy-ethoxy]-quinazoline-4,6-diamineHCID 69320196—
ProductN4-(4,5-Dichloro-2-fluoro-phenyl)-7-{2-[2-(2-{2-[2-ethoxy-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-quinazoline-4,6-diamineHCID 86618845—

Reaction Steps

Compound 41c was prepared as described hereinabove for Compound 41a, using Compound 29c as a starting material.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461166B2
Source datasetuspto-grants-2013_06
ORD IDord-9ab3ad54417f46b5be67cef2b3960f76
Source noteuspto-grants-2013_06