HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol → N4-(4,5-Dichloro-2-fluoro-phenyl)-7-{2-[2-(2-{2-[2-ethoxy-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-quinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol | HCID 69261526 | — |
| Reactant | N4-(4,5-dichloro-2-fluoro-phenyl)-7-[2-ethoxy-ethoxy]-quinazoline-4,6-diamine | HCID 69320196 | — |
| Product | N4-(4,5-Dichloro-2-fluoro-phenyl)-7-{2-[2-(2-{2-[2-ethoxy-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-quinazoline-4,6-diamine | HCID 86618845 | — |
Reaction Steps
Compound 41c was prepared as described hereinabove for Compound 41a, using Compound 29c as a starting material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461166B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9ab3ad54417f46b5be67cef2b3960f76 |
| Source note | uspto-grants-2013_06 |