HCID 58071456, compound → HCID 58071506, compound

HRID 1256015Notes

Reaction equation

HRID 1256015 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:12]2[CH2:17][CH2:16][CH:15]([NH2:18])[C:14]([CH3:20])([CH3:19])[CH2:13]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CO.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([N:12]2[CH2:17][CH2:16][CH:15]([NH2:18])[C:14]([CH3:19])([CH3:20])[CH2:13]2)=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 1

HCID 58071456HCID 58071456, compound2×

Product 1

HCID 58071506HCID 58071506, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (10% wet base, 20 mg) was added to a solution of 1-(3-methoxy-4-nitrophenyl)-3,3-dimethylpiperidin-4-amine (INTERMEDIATE 40) (0.2 g, 0.72 mmol) in methanol (4 mL). The reaction mixture was degassed and was stirred at RT under a hydrogen ballon for 4 h. The catalyst was removed by filtering the mixture through a pad of Celite®. The filtrate was concentrated to give the title product and it was used without further purification. m/z 250.

Workup

  1. customThe reaction mixture was degassed
  2. customThe catalyst was removed
  3. filtrationby filtering the mixture through a pad of Celite®
  4. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-ebd007eb73fb4f8993f32cf81986a9bc
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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