HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(piperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| Reactant | tert-Butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate | HCID 58071495 | — |
| Product | 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(piperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine | HCID 58071450 | — |
Reaction Steps
Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2) and tert-butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate (INTERMEDIATE 8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-394f9ea7a3b44af19d79f803c7426135 |
| Source note | uspto-grants-2013_06 |