HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole → 4-(1H-Indol-3-yl)-N-(2-methoxy-4-(4-(methylamino)piperidin-1-yl)phenyl)-5-methylpyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole | HCID 58071424 | — |
| Reactant | tert-Butyl (1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)(methyl)carbamate | HCID 58071488 | — |
| Product | 4-(1H-Indol-3-yl)-N-(2-methoxy-4-(4-(methylamino)piperidin-1-yl)phenyl)-5-methylpyrimidin-2-amine | HCID 66710114 | — |
Reaction Steps
Starting materials: 3-(2-chloro-5-methylpyrimidin-4-yl)-1H-indole (INTERMEDIATE 1) and tert-butyl 1-(3-methoxy-4-nitrophenyl)piperidin-4-yl(methyl)carbamate (INTERMEDIATE 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-c26f8db48c96400aabcbe3a661c27a7e |
| Source note | uspto-grants-2013_06 |