2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline → HCID 66710261, compound

HRID 1256029Notes

Reaction equation

HRID 1256029 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([C:17]([F:20])([F:19])[F:18])=[CH:4][N:3]=1.[CH3:21][O:22][C:23]1[CH:29]=[C:28]([N:30]2[CH2:35][CH2:34][CH:33]([N:36]3[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]3)[CH2:32][CH2:31]2)[CH:27]=[CH:26][C:24]=1[NH2:25]>>[NH:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([C:6]2[C:5]([C:17]([F:20])([F:19])[F:18])=[CH:4][N:3]=[C:2]([NH:25][C:24]3[CH:26]=[CH:27][C:28]([N:30]4[CH2:35][CH2:34][CH:33]([N:36]5[CH2:37][CH2:38][N:39]([CH3:42])[CH2:40][CH2:41]5)[CH2:32][CH2:31]4)=[CH:29][C:23]=3[O:22][CH3:21])[N:7]=2)=[CH:9]1

Participants

3

Reactant 2

HCID 457899912-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline2×HCID 86661575HCID 86661575, compound2×

Product 1

HCID 66710261HCID 66710261, compound

Procedure

Starting materials: 3-(2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)-1H-indole (INTERMEDIATE 4) and 2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (INTERMEDIATE 27).

Sources & evidence

ORD record
ord-5134a9670c374e0e991a5ecb1ba3edbd
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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