1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine → N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)-5-methylpyrimidin-2-amine

HRID 1256032Notes

Reaction equation

HRID 1256032 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([CH3:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][CH:28]([N:31]([CH3:33])[CH3:32])[CH2:27][CH2:26]2)=[CH:21][C:20]=1[O:34][CH3:35]>>[CH3:32][N:31]([CH3:33])[CH:28]1[CH2:27][CH2:26][N:25]([C:22]2[CH:23]=[CH:24][C:19]([NH:18][C:2]3[N:7]=[C:6]([C:8]4[C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[NH:10][CH:9]=4)[C:5]([CH3:17])=[CH:4][N:3]=3)=[C:20]([O:34][CH3:35])[CH:21]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 574161531-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine2×HCID 580714243-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole2×

Product 1

HCID 58071453N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-4-(1H-indol-3-yl)-5-methylpyrimidin-2-amine

Procedure

Starting materials: 3-(2-chloro-5-methylpyrimidin-4-yl)-1H-indole (INTERMEDIATE 1) and 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine (INTERMEDIATE 28).

Sources & evidence

ORD record
ord-c13048db3036465d83a9a1451996cfcc
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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