HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine → N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-5-fluoro-4-(1H-indol-3-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine | HCID 57416153 | — |
| Reactant | 3-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole | HCID 58071435 | — |
| Product | N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-5-fluoro-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 58071447 | — |
Reaction Steps
Starting materials: 3-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole (INTERMEDIATE 3) and 1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine (INTERMEDIATE 28).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-b6060ff8c651489da1a263cc3a226c24 |
| Source note | uspto-grants-2013_06 |