HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| Reactant | 2-Methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline | HCID 58071463 | — |
| Product | 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine | HCID 58071428 | — |
Reaction Steps
Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2) and 2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (INTERMEDIATE 26).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9ba8547886394c98b28ca0df3fae0b09 |
| Source note | uspto-grants-2013_06 |