3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-Chloro-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 1256037Notes

Reaction equation

HRID 1256037 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([Cl:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[C:24]([O:25][CH3:26])=[CH:23][C:22]([N:27]2[CH2:32][CH2:31][CH:30]([N:33]([CH3:35])[CH3:34])[CH2:29][CH2:28]2)=[C:21]([CH3:36])[CH:20]=1>>[Cl:17][C:5]1[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[N:7][C:2]([NH:18][C:19]2[CH:20]=[C:21]([CH3:36])[C:22]([N:27]3[CH2:28][CH2:29][CH:30]([N:33]([CH3:35])[CH3:34])[CH2:31][CH2:32]3)=[CH:23][C:24]=2[O:25][CH3:26])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indole2×HCID 580714601-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidin-4-amine2×

Product 1

HCID 580714995-Chloro-N-(4-(4-(dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine

Procedure

Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2) and 1-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidin-4-amine (INTERMEDIATE 30).

Sources & evidence

ORD record
ord-dd284532523f428a8badd0923a7efd04
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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