3-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole → N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)-5-methylpyrimidin-2-amine

HRID 1256038Notes

Reaction equation

HRID 1256038 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([CH3:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[C:24]([O:25][CH3:26])=[CH:23][C:22]([N:27]2[CH2:32][CH2:31][CH:30]([N:33]([CH3:35])[CH3:34])[CH2:29][CH2:28]2)=[C:21]([CH3:36])[CH:20]=1>>[CH3:35][N:33]([CH3:34])[CH:30]1[CH2:29][CH2:28][N:27]([C:22]2[C:21]([CH3:36])=[CH:20][C:19]([NH:18][C:2]3[N:7]=[C:6]([C:8]4[C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[NH:10][CH:9]=4)[C:5]([CH3:17])=[CH:4][N:3]=3)=[C:24]([O:25][CH3:26])[CH:23]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 580714243-(2-Chloro-5-methylpyrimidin-4-yl)-1H-indole2×HCID 580714601-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidin-4-amine2×

Product 1

HCID 58071474N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxy-5-methylphenyl)-4-(1H-indol-3-yl)-5-methylpyrimidin-2-amine

Procedure

Starting materials: 3-(2-chloro-5-methylpyrimidin-4-yl)-1H-indole (INTERMEDIATE 1) and 1-(4-amino-5-methoxy-2-methylphenyl)-N,N-dimethylpiperidin-4-amine (INTERMEDIATE 30).

Sources & evidence

ORD record
ord-5ca5834e73544c54bcd5fc6022c3d8c4
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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