HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxy-5-methylphenyl]-5-chloro-4-(1H-indol-3-yl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| Reactant | HCID 66710201 | HCID 66710201 | — |
| Product | 2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxy-5-methylphenyl]-5-chloro-4-(1H-indol-3-yl)- | HCID 58071425 | — |
Reaction Steps
Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2) tert-butyl 1-(4-amino-5-methoxy-2-methylphenyl)piperidin-4-ylcarbamate (INTERMEDIATE 29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-c54f55ad808341e5926766eac9f41589 |
| Source note | uspto-grants-2013_06 |