3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → HCID 58071443, compound

HRID 1256042Notes

Reaction equation

HRID 1256042 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[C:5]([Cl:17])=[CH:4][N:3]=1.[F:18][C@@H:19]1[CH2:23][CH2:22][N:21]([CH:24]2[CH2:29][CH2:28][N:27]([C:30]3[C:36]([CH3:37])=[CH:35][C:33]([NH2:34])=[C:32]([O:38][CH3:39])[CH:31]=3)[CH2:26][CH2:25]2)[CH2:20]1>>[Cl:17][C:5]1[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[N:7][C:2]([NH:34][C:33]2[CH:35]=[C:36]([CH3:37])[C:30]([N:27]3[CH2:28][CH2:29][CH:24]([N:21]4[CH2:22][CH2:23][C@@H:19]([F:18])[CH2:20]4)[CH2:25][CH2:26]3)=[CH:31][C:32]=2[O:38][CH3:39])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indole2×HCID 58071438HCID 58071438, compound2×

Product 1

HCID 58071443HCID 58071443, compound

Procedure

Starting materials: 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2) and (R)-4-(4-(3-fluoropyrrolidin-1-yl)piperidin-1-yl)-2-methoxy-5-methylaniline (INTERMEDIATE 36).

Sources & evidence

ORD record
ord-5b76ec28fc0f4006b2633871285a051c
Source dataset
uspto-grants-2013_06
Patent number
US08461170B2

Reaction notes

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