1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) → HCID 66710172, compound

Participants

Reaction Steps

5-Bromo-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine (Example 27, 155 mg, 0.27 mmol), zinc powder (0.176 mg, 2.69 μmol), dicyanozinc (47.4 mg, 0.40 mmol), Pd2dba3 (12.31 mg, 0.01 mmol), and xantphos (15.56 mg, 0.03 mmol) in DMA (1.5 mL) were heated at 130° C. for 2 h. The reaction mixture was purified by chromatography on silica gel (10% MeOH/1% NH4OH in DCM) to give the title product (73.0 mg, 52.0%).

Provenance & Evidence