HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R,4S)-1-(4-amino-3-methoxyphenyl)-3-fluoropiperidin-4-amine → (cis)-N-(4-(4-amino-3-fluoropiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R,4S)-1-(4-amino-3-methoxyphenyl)-3-fluoropiperidin-4-amine | HCID 58071469 | — |
| Reactant | (trans)-N-(4-(4-amino-3-fluoropiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 66710159 | — |
| Product | (cis)-N-(4-(4-amino-3-fluoropiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 58071491 | — |
Reaction Steps
Starting material: (cis)-(±)-1-(4-amino-3-methoxyphenyl)-3-fluoropiperidin-4-amine (INTERMEDIATE 65) and 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (INTERMEDIATE 2). The NMR spectra of the title compound was identical to Example 33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461170B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-bb06422b1b5b48eba619a8503ec412be |
| Source note | uspto-grants-2013_06 |