反应详情

2,2,2-trifluoro-1-(indolin-1-yl)ethanone (5 g, 16 mmol) was added to neat chlorosulfonic acid at 0° C. and then the solution was allowed to warm to rt and stirred for an additional 2 hrs. Reaction mixture was slowly added to ice chips and stirred for 10 min then filtered off 4.2 g of the title compound as a dark red colored solid.

1. customReaction mixture
2. additionwas slowly added to ice chips
3. stirringstirred for 10 min
4. filtrationthen filtered off 4.2 g of the title compound as a dark red colored solid