HCID 58413845, compound → HCID 67173701, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-N-(5-fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-nitrobenzenesulfonamide (0.5 g, 1.3 mmol), iron powder (0.36 g, 6.5 mmol) in AcOH (10 mL) was heated to 50° C. over night and monitored by LC/MS. The mixture was filtered, washed with EtOAc then AcOH, and evaporated under vacuum. Preparative HPLC was applied for the purification and give title product as yellow powder yield 36.3 mg (2%). 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.71 (s, 1H), 7.64 (d, J=8 Hz, 1H), 7.44 (d, J=8.8 Hz, 1H), 7.20 (d, J=10 Hz, 1H), 6.65 (d, J=2 Hz, 1H), 6.41 (dd, J=8.8, 2.4 Hz, 1H), 4.88 (s, 2H); MS (ESI): m/z=355.0 (M−H, negative).

Provenance & Evidence