Acetic Anhydride → N-(3-ethylphenyl)acetamide

HRID 1256074Notes

Reaction equation

HRID 1256074 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6])[CH3:2].[CH3:10][C:11](OC(C)=O)=[O:12]>>[CH2:1]([C:3]1[CH:4]=[C:5]([NH:6][C:11](=[O:12])[CH3:10])[CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 114753-Ethylaniline

Product 1

HCID 4341261N-(3-ethylphenyl)acetamide

Procedure

3-Ethylaniline (2 g, 0.016 mol) was added slowly in portion into neat Ac2O (8 ml) at 0° C. After removed ice bath and the reaction was stirred at room temperature for 2 hour. The solvent was removed in vacuo and extracted with EtOAc, washed with water and brine, dried over Na2SO4. Concentrated to get crude N-(3-ethylphenyl)acetamide as light yellow solid.

Workup

  1. customAfter removed ice bath
  2. customThe solvent was removed in vacuo
  3. extractionextracted with EtOAc
  4. washwashed with water and brine
  5. dry with materialdried over Na2SO4
  6. concentrationConcentrated

Sources & evidence

ORD record
ord-d37ebfb7daad47bfb07191e947503919
Source dataset
uspto-grants-2013_06
Patent number
US08461134B2

Reaction notes

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