Chlorosulfonic acid → Methyl 2-(2-(chlorosulfonyl)-5-(2,2,2-trifluoroacetamido) phenyl)acetate

HRID 1256078노트

반응식

HRID 1256078 반응식
[F:1][C:2]([F:18])([F:17])[C:3]([NH:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH:9]=[CH:10][CH:11]=1)=[O:4].[Cl:19][S:20](O)(=[O:22])=[O:21]>>[Cl:19][S:20]([C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[C:2]([F:17])([F:18])[F:1])=[CH:7][C:8]=1[CH2:12][C:13]([O:15][CH3:16])=[O:14])(=[O:22])=[O:21]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 86655205Methyl 2-(3-(2,2,2-trifluoroacetamido)phenyl)acetate

생성물 1

HCID 86655207Methyl 2-(2-(chlorosulfonyl)-5-(2,2,2-trifluoroacetamido) phenyl)acetate

실험 절차

To methyl 2-(3-(2,2,2-trifluoroacetamido)phenyl)acetate (1.0 g, 3.8 mmol) at 0° C. was added ClSO2OH (2.3 g, 19.2 mmol). Then the mixture was stirred at room temperature for 2 hr. The mixture was poured into ice water and extracted with DCM. The combined organic layer were dried and concentrated to give the crude product methyl 2-(2-(chlorosulfonyl)-5-(2,2,2-trifluoroacetamido)phenyl)acetate. The product used directly to next reaction.

후처리

  1. extractionextracted with DCM
  2. customThe combined organic layer were dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b16a0a72aa9d40cc80a5079fc1617a8b
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461134B2

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