Water → HCID 67172008, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(3-(ethylthiomethyl)phenyl)acetamide (1 g, 5 mmol) in DCM (10 mL) was added mCPBA (2.4 g, 14 mol). The reaction mixture was stirred at 40° C. overnight. Then water was added, the organic layer was separated and washed with an aqueous of NaHCO3, dried over Na2SO4, concentrated and purified by silica gel chromatography (petroleum ether:EtOAc=1:0 to 5:1) to give N-(3-(ethylsulfonylmethyl)phenyl)acetamide (1 g, 87% yield) as a white solid. 1H NMR: (400 MHz, CDCl3) δ 7.84 (s, 1H), 7.61 (s, 1H), 7.41 (d, 1H), 7.24 (t, 1H), 7.14 (d, 1H), 4.14 (s, 2H), 2.90-2.85 (m, 2H), 2.12 (s, 3H), 1.34 (t, 3H).

Provenance & Evidence