Chlorosulfonic acid → HCID 87295833, compound

HRID 1256149Notes

Reaction equation

HRID 1256149 reaction equation
[CH2:1]([S:3]([CH2:6][C:7]1[CH:8]=[C:9]([NH:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)(=[O:5])=[O:4])[CH3:2].[OH:17][S:18]([Cl:21])(=O)=[O:19]>C(Cl)Cl>[C:14]([NH:13][C:9]1[CH:10]=[CH:11][C:12]([S:18]([Cl:21])(=[O:19])=[O:17])=[C:7]([CH2:6][S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])[CH:8]=1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 67172008HCID 67172008, compound

Product 1

HCID 87295833HCID 87295833, compoundYield 58.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To N-(3-(ethylsulfonylmethyl)phenyl)acetamide (1 g, 4 mmol) was added HOSO2Cl (4.8 g) dropwise at 0° C. The mixture was stirred at r.t. for 3 hrs. The reaction mixture was diluted with DCM and washed with water, the organics was dried over Na2SO4, concentrated under reduced pressure to give 4-acetamido-2-(ethylsulfonylmethyl)benzene-1-sulfonyl chloride (0.8 g, yield 57%).

Workup

  1. washwashed with water
  2. dry with materialthe organics was dried over Na2SO4
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0f7beac453db48a29a0bf30129fde84e
Source dataset
uspto-grants-2013_06
Patent number
US08461134B2

Reaction notes

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