反应详情

A solution of 2,2,2-trifluoro-N-(3-(2-(methylthio)ethyl)phenyl)acetamide (4 g, 15 mmol) and m-CPBA (7.9 g, 45 mmol) in DCM (30 mL) was heated to reflux overnight. Aqueous solution of sodium thiosulfate (10 mL) was added. The solid was filtered from the mixture solution. The aqueous layer was extracted by ethyl acetate 3 times. The combined organic phase was washed with brine, dried over sodium sulfate and concentrated to give 2,2,2-trifluoro-N-(3-(2-(methylsulfonyl)ethyl)phenyl)acetamide (4 g, yield 89%). 1H NMR: 400 MHz CDCl3 δ 7.85 (s, 1H), 7.50-7.49 (m, 1H), 7.36-7.28 (m, 2H), 7.07-7.05 (m, 1H), 3.26-3.22 (m, 2H), 3.14-3.10 (m, 2H), 2.79 (s, 3H).

1. temperatureto reflux overnight
2. filtrationThe solid was filtered from the mixture solution
3. extractionThe aqueous layer was extracted by ethyl acetate 3 times
4. washThe combined organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated