Pyridine → HCID 67173130, compound

Participants

Reaction Steps

To a stirred solution of 2-(oxazol-2-ylmethyl)-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride (450 mg, 1.2 mmol) and 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (212 mg, 1.42 mmol) in 10 mL of ACN was added pyridine (228 uL, 2.8 mmol) dropwise. The reaction mixture was stirred at room temperature for 3 hours. After the mixture was concentrated, the residue was extracted with ethyl acetate and washed with water, 1N HCl and brine. The organic layer was dried over Na2SO4 and concentrated to give the desired compound as a yellow residue (540 mg, yield 92%). A small portion of the crude mixture was purified by prep HPLC (SunFire Prep C18 OBD 5 uM 30×50 mm column) to give the title compound as a yellow solid.

Provenance & Evidence