Pyridine → HCID 67312003, compound

Participants

Reaction Steps

To a stirred solution of 2-((5-propyl-1,3,4-oxadiazol-2-yl)methyl)-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride (430 mg, 1.05 mmol) and 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (234 mg, 1.57 mmol) in 5 mL of ACN was added pyridine (253 uL, 3.13 mmol) dropwise. The reaction mixture was stirred at room temperature for 16 hours. After the mixture was concentrated, the residue was extracted with ethyl acetate and washed with water, 1N HCl and brine. The organic layer was dried over Na2SO4 and concentrated to give the desired compound as a yellow solid (410 mg, yield 75%).

Provenance & Evidence