Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86655245 | HCID 86655245 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 62506330 | HCID 62506330 | 90.2% |
Reaction Steps
To the solution of N-(2-(benzylthio)-5-nitrophenyl)-2,2,2-trifluoroacetamide (17.5 g, 49 mmol) in methanol (100 ml), added ammonia (15 ml, 7N in CH3OH). The reaction was heated at 60° C. for 2 hours. Then concentrated, extracted with EtOAc, washed with water and brine, dried over Na2SO4. Concentrated to give 11.5 g 2-(benzylthio)-5-nitroaniline as product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08461134B2 |
|---|
| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-19d0744cf1a14d3ba7851a3884f364e6 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
