反应详情

温度

160 °C

In a sealed reactor, 500 mg (1.23 mmol, 1 eq) of 7-bromo-2-chloro-1,5-naphthyridine and 7 mL (41.6 mmol, 33 eq) of 20% aqueous ammonia solution were introduced in 7 mL of dioxane. The mixture was stirred at 160° C. for 24 h. The mixture was allowed to reach rt and water was added. Aqueous layer was extracted with ethyl acetate. Organic layers were dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by column chromatography using methylene chloride and then methylene chloride/ethanol: 98/2 as eluent. The solvent was evaporated to dryness to afford 220 mg of white powder with 80% yield.

1. customto reach rt
2. extractionAqueous layer was extracted with ethyl acetate
3. dry with materialOrganic layers were dried over Na2SO4
4. filtrationfiltered
5. customevaporated to dryness
6. customThe residue was purified by column chromatography
7. customThe solvent was evaporated to dryness