Trifluoroacetic acid → HCID 178524087, compound

Participants

Reaction Steps

A 250 ml round-bottomed flask is charged with 1.46 g of 5-(2,6-difluorophenyl)-1-(dimethylsulphamoyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid in 100 ml of DCM and then 20 ml of TFA are added. The mixture is stirred at RT for 16 h. It is concentrated under RP and the solid obtained is taken up in 30 ml of saturated aqueous NaHCO3 solution and extracted with three times 30 ml of AcOEt. The aqueous phase is acidified to a pH of 1 by addition of 37% HCl and extracted with AcOEt. The organic phase is washed with saturated NaCl solution, dried over MgSO4, filtered and concentrated under RP to give 927 mg of 5-(2,6-difluorophenyl)-2H-pyrazolo[4,3-c]isoquinoline-7-carboxylic acid (beige solid), LC-MS-DAD-ELSD: 326(+)=(M+H)(+).

Provenance & Evidence