反应详情

To a CHCl3 (120 mL) solution of the compound (1.00 g) obtained in Step 51-1, MnO2 (13.6 g) was added and the mixture was stirred at room temperature for 4 hours. The reaction mixture was filtrated through a pad of Celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel 60 N, mobile phase MeOH/CHCl3=0/100 to 10/90; v/v) to obtain 7-acetyl-3,4-dihydroquinolin-2(1H)-one (0.58 g, a colorless solid).

1. filtrationThe reaction mixture was filtrated through a pad of Celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography (silica gel 60 N, mobile phase MeOH/CHCl3=0/100 to 10/90; v/v)