反应详情

温度

100 °C

Step R1-3: To a suspension of 2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonitrile (160 g) in HCO2H (1.6 L) was added Raney Nickel Catalyst (slurry in water, 160 g) at room temperature over 30 minutes. The mixture was heated at 100° C. for 2 hours. After cooling to room temperature, the reaction mixture was filtrated through a pad of Celite and washed with HCO2H. The filtrate was concentrated to obtain a solid. The solid was stirred with water (1.3 L) and filtrated to obtain 2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehyde as a pale brown solid (156 g).

1. temperatureAfter cooling to room temperature
2. filtrationthe reaction mixture was filtrated through a pad of Celite
3. washwashed with HCO2H
4. concentrationThe filtrate was concentrated
5. customto obtain a solid
6. filtrationfiltrated