Potassium Carbonate → HCID 44250353, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide (4G, 44 mg, 1.0 equivalent), 4-fluorophenylboronic acid (1.2 equivalents), Pd(OAc)2 (0.05 equivalent), and K2CO3 (4.0 equivalents) in DME/H2O was warmed to 110° C. in a microwave reactor. The reaction mixture was cooled to room temperature, diluted with methanol, filtered, and purified via preparative HPLC to afford the title compound. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.37 (s, 9 H) 6.50 (d, J=2.26 Hz, 1 H) 7.23-7.32 (m, 1 H) 7.56 (d, J=8.29 Hz, 2 H) 7.89 (d, J=8.29 Hz, 2 H) 8.11 (d, J=2.26 Hz, 1 H) 8.12-8.18 (m, 2 H) 8.25 (s, 1 H) 8.67 (s, 1 H); ESI-MS: m/z 389 (M+H)+.

Provenance & Evidence