HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one | HCID 59338833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime | HCID 72258470 | — |
Reaction Steps
Following General Procedure P, 1-[6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one (Compound 78), (24 mg, 0.07 mmol), NH2OMe—HCl (23 mg, 0.25 mmol) and pyridine (21 mg, 0.28 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-28bcb12bc8624d6c93962d8249bed849 |
| Source note | uspto-grants-2010_06 |