Pyrrolidine → HCID 66878313, compound

Participants

Reaction Steps

A solution of N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide (4G, 44 mg, 1.0 equivalent) and pyrrolidine (4.0 equivalents) in DMF (0.10 M with respect to 4G) was stirred at 80° C. for 1 h. After cooling, the mixture was diluted with methanol and purified by preparative LC-MS to afford the titled compound (76%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.26 (s, 6 H), 1.85-2.07 (m, 4 H), 2.33 (s, 3 H), 3.47 (s, 2 H), 3.96 (br. s., 4 H), 6.13 (s, 1 H), 6.75 (s, 1 H), 7.53 (d, J=8.59 Hz, 2 H), 7.97 (d, J=8.59 Hz, 2 H), 10.89 (s, 1 H). ESI-MS: m/z 394.3 (M+H)+.

Provenance & Evidence