反应详情

A solution of the above carbamate (0.244 g, 0.035 mmol) in a mixture of 10 mL CH2Cl2 and 5 mL TFA was stirred at room temperature for 2 hrs. The mixture was diluted with CH2Cl2 and then made basic with dil. aq. NH3. The organic layer was dried and concentrated to give a quantitative yield of N-[2-({4-[4-[6-amino-2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1-piperazinyl}sulfonyl)ethyl]-N,N-dimethylamine: 1H NMR (CDCl3) δ 7.35 (t, JHF=53.8 Hz, 1H), 7.15 (d, J=1.9 Hz, 1H), 6.22 (d, J=1.9 Hz, 1H), 3.98 (m, 7H), 3.90-3.75 (m, 10H), 3.38 (m, 4H), 3.11 (dd, J=8.1, 6.5 Hz, 2H), 2.78 (dd, J=8.1, 6.4 Hz, 2H), 2.26 (s, 6H).

1. customThe organic layer was dried
2. concentrationconcentrated