Pyridine → HCID 59627868, compound

Participants

Reaction Steps

A solution of di-tert-butyl(3-amino-6-phenylpyridin-2-yl)imidodicarbonate (351 mg, 0.910 mmol, theoretical yield from previous reaction), THF (1.82 mL) and methylene chloride (1.82 mL) was cooled 0° C. and pyridine (0.294 mL, 3.64 mmol) and benzyl chloroformate (0.256 mL, 1.82 mmol) were added dropwise. The reaction was stirred for 2 h, diluted with EtOAc and washed with 1M aq. HCl2×, sat. aq. NaHCO3, brine, dried (MgSO4) and concentrated to afford a residue purified via MPLC, silica cartridge, 5-20% EtOAc in heptanes to afford the product as a clear light orange oil. MS cal'd 520 (M+H)+, exp 520 (M+H)+.

Provenance & Evidence