HCID 91030395, compound → HCID 59627857, compound

Participants

Reaction Steps

To a suspension of tert-butyl(4-{[(3-nitro-6-phenylpyridin-4-yl)amino]carbonyl}benzyl)carbamate (30 mg, 0.067 mmoll) in MeOH (2 mL) was added Pd on carbon (˜10 mg) and the reaction flask was thoroughly flushed with H2. The reaction was then allowed to proceed at RT under a H2 balloon. During the course of reaction, the mixture becomes a homogenous solution. The reaction mixture was filtered through a silica gel pad and the silica gel was washed thoroughly with MeOH. The Me0H layer was concentrated and residue was purified by HPLC. 1H NMR (600 MHz. d6-DMSO) δ 9.78 (s, 1H), 8.15 (s, 1H), 7.96 (s, 1H), 7.91 (d, J=7.8 Hz, 2H), 7.87 (dd, J=8.4, 1.2 Hz, 2H), 7.48 (t, J=6 Hz, 1H), 7.37 (m, 4H), 7.27 (m, 1H), 5.32 (bs, 2H), 4.17 (d, J=6 Hz, 2H), 1.37 (s, 9H); MS: cal'd 419 (M+H)+, exp 419 (M+H)+.

Provenance & Evidence