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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1256691Generated: November 2, 2026

2',4'-Dihydroxyacetophenone → 2'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone

https://huagongshe.com/reaction/1256691

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2',4'-DihydroxyacetophenoneHCID 6990—
ReactantPropanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 11745—
Product2'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenoneHCID 57762881—

Reaction Steps

This compound was synthesized from 2′,4′-dihydroxyacetophenone and ethyl bromoisobutyrate (1 eq) according to general method 4 described earlier. It was purified by chromatography on silica gel (elution: cyclohexane/ethyl acetate 9:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461212B2
Source datasetuspto-grants-2013_06
ORD IDord-29c584ba8dca4e14a02eb0e254752754
Source noteuspto-grants-2013_06