Aluminum(III) Chloride → 1-(4-Chloro-2-hydroxyphenyl)ethanone

HRID 1256693Notes

Reaction equation

HRID 1256693 reaction equation
[OH:1][C:2]1[CH:7]=[C:6](OC(C(OCC)=O)(C)C)[CH:5]=[CH:4][C:3]=1[C:17](=[O:19])[CH3:18].[Cl-:20].[Al+3].[Cl-].[Cl-]>>[Cl:20][C:6]1[CH:5]=[CH:4][C:3]([C:17](=[O:19])[CH3:18])=[C:2]([OH:1])[CH:7]=1

Participants

3

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 577628812'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone2×

Product 1

HCID 10515131-(4-Chloro-2-hydroxyphenyl)ethanone

Conditions

Temperature
200 °C

Procedure

3-chlorophenyl acetate (starting material 2) was mixed with aluminium chloride (3 eq). The mixture was heated at 200° C. for 1 hour. The reaction medium was cooled. to room temperature then poured in ice. The aqueous phase was extracted with methylene chloride which was dried on magnesium sulfate then vacuum evaporated.

Workup

  1. temperatureThe reaction medium was cooled
  2. additionto room temperature then poured in ice
  3. extractionThe aqueous phase was extracted with methylene chloride which
  4. customwas dried on magnesium sulfate
  5. customvacuum evaporated

Sources & evidence

ORD record
ord-bc8c072b52194239a7f1703ccbe179eb
Source dataset
uspto-grants-2013_06
Patent number
US08461212B2

Reaction notes

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