反应详情

To (6-bromo-pyridazin-3-yl)-(4-chloro-benzyl)-amine (522, 0.560 g, 1.88 mmol) in tetrahydrofuran (45.0 mL), under an atmosphere of nitrogen at −78° C., was added n-butyllithium (2.50 M in hexane, 0.760 mL) slowly. After 10 minutes, 1,2-bis-(chloro-dimethyl-silanyl)-ethane (0.201 g, 0.94 mmol) in tetrahydrofuran (5.0 mL) was added to the reaction. The reaction mixture was allowed to stir at room temperature for 3 hours. The reaction was cooled to −78° C., followed by addition of 1.70 M of tert-butyllithium in hexane (1.20 mL) slowly. The reaction was stirred for 20 minutes, followed by addition of a solution of CuCN.2LiCl (0.6 M in tetrahydrofuran, 3.00 mL) and 3-chloromethyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester (512, 0.47 g, 1.8 mol) in tetrahydrofuran (10.0 mL). After 30 minutes, the reaction was allowed to warm to room temperature for 10 minutes. The reaction was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was treated with trifluoroacetic acid (1.0 mL) dissolved in dichloromethane (10.0 mL) for 10 minutes. The reaction was concentrated, poured into aqueous potassium carbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified with silica gel column chromatography eluting with 60% ethyl acetate in hexane to give the desired compound (523, 0.10 g, 23.8%). MS (ESI) [M+H+]+=450.1.

1. temperatureThe reaction was cooled to −78° C.
2. stirringThe reaction was stirred for 20 minutes
3. waitAfter 30 minutes
4. temperatureto warm to room temperature for 10 minutes
5. extractionextracted with ethyl acetate
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. filtrationfiltered
8. additionThe filtrate was treated with trifluoroacetic acid (1.0 mL)
9. dissolutiondissolved in dichloromethane (10.0 mL) for 10 minutes
10. concentrationThe reaction was concentrated
11. additionpoured into aqueous potassium carbonate
12. extractionextracted with ethyl acetate
13. dry with materialThe organic layer was dried over anhydrous sodium sulfate
14. filtrationfiltered
15. concentrationThe filtrate was concentrated
16. custompurified with silica gel column chromatography
17. washeluting with 60% ethyl acetate in hexane