HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → Diethyl [(4-cyanophenyl)methyl]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Product | Diethyl [(4-cyanophenyl)methyl]propanedioate | HCID 14370114 | 66.3% |
Reaction Steps
In the same manner as in Example 6 (1), a crude product was obtained using diethyl malonate (13.6 g) and 4-cyanobenzyl bromide (16.7 g). This was purified by silica gel column chromatography to give the title compound (15.5 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461209B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-17856c63e9f7444084c4e1997d7152dc |
| Source note | uspto-grants-2013_06 |