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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1256883Generated: November 1, 2026

Diethyl Malonate → Diethyl 2-(2-(hydroxy(oxido)amino)benzyl)malonate

https://huagongshe.com/reaction/1256883

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl MalonateHCID 7761—
Reactantalpha-Bromo-2-nitrotolueneHCID 77569—
ProductDiethyl 2-(2-(hydroxy(oxido)amino)benzyl)malonateHCID 30927474.8%

Reaction Steps

In the same manner as in Example 6 (1), a crude product was obtained using diethyl malonate (10.1 g) and 2-nitrobenzyl bromide (13.6 g). This was purified by silica gel column chromatography to give the title compound (13.9 g) as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08461209B2
Source datasetuspto-grants-2013_06
ORD IDord-c3b802a9cfcf4287b06b86d3869b0b9b
Source noteuspto-grants-2013_06