HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → Triethyl 2-[4-(trifluoromethoxy)phenyl]ethane-1,1,1-tricarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Triethyl methanetricarboxylate | HCID 80471 | — |
| Reactant | 1-(Bromomethyl)-4-(trifluoromethoxy)benzene | HCID 142785 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Triethyl 2-[4-(trifluoromethoxy)phenyl]ethane-1,1,1-tricarboxylate | HCID 68511908 | 100.1% |
Reaction Steps
To a solution of triethyl methanetricarboxylate (4.55 g) in DMF (40 mL) were added 4-(trifluoromethoxy)benzyl bromide (5.00 g), potassium iodide in catalytic amount and potassium carbonate (4.07 g), and the mixture was stirred at room temperature for 3 hr. Ethyl acetate (200 mL) and water (100 mL) were added to extract the reaction mixture. The extract was washed sequentially with water and brine, and concentrated under reduced pressure to give the title compound (7.97 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461209B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-f801f66264d84429acaf4c1228a48aaa |
| Source note | uspto-grants-2013_06 |