4-Fluorobenzoyl chloride → HCID 86645214, compound

HRID 1256889Notes

Reaction equation

HRID 1256889 reaction equation
[C:1]([NH:9][C:10]1[C:40]([CH3:41])=[CH:39][C:13]([CH2:14][CH:15]([C:23]([NH:25][S:26]([C:29]2[CH:38]=[CH:37][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=2)(=[O:28])=[O:27])=[O:24])[C:16]([N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[O:17])=[CH:12][C:11]=1[CH3:42])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:43]C1C=CC(C(Cl)=O)=CC=1>>[CH2:21]([N:18]([CH2:19][CH3:20])[C:16](=[O:17])[CH:15]([CH2:14][C:13]1[CH:39]=[C:40]([CH3:41])[C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[F:43])=[C:11]([CH3:42])[CH:12]=1)[C:23]([NH:25][S:26]([C:29]1[CH:38]=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=1)(=[O:27])=[O:28])=[O:24])[CH3:22]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 86645215HCID 86645215, compound

Product 1

HCID 86645214HCID 86645214, compound

Procedure

In the same manner as in Example 9, a crude product was obtained using the compound (331 mg) obtained in Example 137 (4) and 4-fluorobenzoyl chloride (82 μL). This was purified by silica gel column chromatography to give the title compound (239 mg) as a white solid.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-8abf2840d6734135a90bc1f1d9546e56
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

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