HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Piperazin-1-yl)pyridine-3-carbonitrile → 2-(4-cyanobenzyl)-3-[4-(5-cyano-2-pyridyl)-1-piperazinyl]-N-(2-naphthylsulfonyl)-3-oxopropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Piperazin-1-yl)pyridine-3-carbonitrile | HCID 2737184 | — |
| Reactant | 2-(4-cyanobenzyl)-N,N-diethyl-N'-(2-naphthylsulfonyl)malonamide | HCID 86645217 | — |
| Product | 2-(4-cyanobenzyl)-3-[4-(5-cyano-2-pyridyl)-1-piperazinyl]-N-(2-naphthylsulfonyl)-3-oxopropanamide | HCID 68512976 | 75.8% |
Reaction Steps
In the same manner as in Example 1 (4), a crude product was obtained using the compound (300 mg) obtained in Example 111 (4) and N-(5-cyano-2-pyridyl)piperazine (166 mg). This was purified by silica gel column chromatography to give the title compound (284 mg) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461209B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-122e439801ff4abbab4e5fdc7dd8ee1b |
| Source note | uspto-grants-2013_06 |