N-Ethylaniline → HCID 68511713, compound

HRID 1256898Notes

Reaction equation

HRID 1256898 reaction equation
[CH2:1]([N:3]([CH2:32][CH3:33])[C:4](=[O:31])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])=[O:7])[CH3:2].C(N[C:37]1[CH:42]=CC=[CH:39][CH:38]=1)C>>[CH2:32]([N:3]([C:1]1[CH:39]=[CH:38][CH:37]=[CH:42][CH:2]=1)[C:4](=[O:31])[CH:5]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)[C:6]([NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)(=[O:10])=[O:11])=[O:7])[CH3:33]

Participants

3

Reactant 2

HCID 7670N-EthylanilineHCID 86645218HCID 86645218, compound

Product 1

HCID 68511713HCID 68511713, compoundYield 75.2%

Procedure

In the same manner as in Example 1 (4), a crude product was obtained using the compound (550 mg) obtained in Example 112 (4) and N-ethylaniline (161 mg). This was purified by silica gel column chromatography to give the title compound (456 mg) as a white powder.

Workup

  1. customThis was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-5736c025b5674f659fe2f403b1d6c098
Source dataset
uspto-grants-2013_06
Patent number
US08461209B2

Reaction notes

Loading…